More than 120 groups are expected to take part in Saturday's anti-racism demonstration.
The protest, which is being organised by United Against Racism, will begin at noon at Writer's Square and march to City Hall.
It occurs after several hundred people turned out on Friday night for a counter-protest against several hundred anti-immigration protestors in the city.
Donegall Square North and Wellington Place were closed to traffic for several hours, while Belfast City Hall was guarded by a large number of police officers and obstacles.
People at the anti-immigration protest were seen holding signs with slogans such as "Shankill Road says no to illegal immigration" and chanting "Send them home".
Trade union banners and signs with anti-racism messages were held aloft at the counter-protest, with chants of "When migrant lives are under attack, what do we do? Stand up, fight back" and " Belfast is anti-fascist".
By early evening, most of the anti-immigration protesters left the area.
Police have planned a significant operation ahead of the planned protests over the weekend.
More than 120 groups are expected to take part in Saturday's anti-racism demonstration.
A spokesperson for the United Against Racism group said: " Belfast is an inclusive and diverse city that will not be bowed by racist hate.
"On Saturday, we are urging all who oppose division to join the march and show that those who peddle racism do not speak for the majority.
"We want all trade unions, community groups, and all progressive political parties and activist groups to be there
"Violent racists must not be allowed to control our streets or control the narrative around the problems facing our communities.
"When progressives campaign for social change, for investment in public services, or for the rights we all deserve, the far-right are never to be seen.
"In every corner of this island we need to build an anti-racism movement that challenges hate, but also provides solutions to the issues we must overcome together.
"Unity is the key to overcoming hate, and unity is the key to uplifting all who have been let down by those in power.
"We must inspire confidence in all who have been intimidated and are fearful in their own homes. Belfast welcomes diversity and we are calling everyone out to showcase it."
Rioting erupted across the UK due to misinformation online that the suspect in the stabbing of three young girls in Southport last month was a Muslim asylum seeker.
Since last Saturday, businesses, homes and people have been targeted by anti-immigrant protesters across Belfast .
A total of 26 people have been arrested as part of investigations into disorder in recent days, with 22 people charged.